Eugene Domingo is a Filipino film and theater actress, comedienne and host. She has been listed as one of the highly paid actresses in acting industry; her net worth has been stated to be around $245 million dollars. She has performed in lead and supporting roles and in various genres of the film industry. She was popularly known as side-kick of the Philippines Queen of Comedy, Ai-Ai delas Alas in the Ang Tanging Ina series, until she was launched on her very first lead role in Kimmy Dora: Kambal sa Kiyeme (2009) which eventually got a sequel in 2012.

On the list Domingo's other notable films include Bahay Kubo wherein she was awarded on her first "Best Supporting Actress" award. Her most successful film to date is the Cinemalaya entry, Ang Babae Sa Septic Tank which holds the record for the highest grossing independent film in Filipino entertainment history. The film was also chosen by the Film Academy of the Philippines to represent the Philippines in the Best Foreign Language Film category of the 84th Academy Awards. Domingo achieved "Best Actress" awards, at the Cinemalaya (2011) and 10th Gawad Tanglaw for Films (2012). She also received the "People's Choice Award for Best Actress" at the 6th Asian Film Awards (2012) in Hong Kong and "Best Actress" award at the 3rd Pau International Film Festival in France.

Domingo is the only actress in the Philippine entertainment history to have participated in six films (Working Girls 2010, Here Comes the Bride, Mamarazzi, Petrang Kabayo, RPG: Metanoia, Ang Tanging Ina Mo (Last na 'To!)) produced by eight Filipino production companies (GMA Films, Regal Films, Unitel Productions, OctoArts Films, Quantum Films, VIVA Films, Ambient Media, Star Cinema) within a year. Domingo holds the record of being the first lead actress in Philippine cinema to star in the most films — seven — in a year. She was nominated as "Best Actress in a Play award" for her role at the International Theater Award and eventually hailed as "Best Actress in Theater role" for Bona at the 25th Aliw Awards (2012).