Moving to LA brought significant improvement in Wayne's acting skills. He quickly turned that improvement into opportunity when he bagged a role in the comedy TV series Whose line is it Anyway? in 1998. Brady was able to make a breakthrough in television with this stint and went on to win an Emmy for Outstanding Individual Performance in 2003. The show ran on ABC from 1998 to 2007. It made a comeback on The CW in 2013 and was renewed for a thirteenth season on October 24, 2016.
Brady credits talent and family-friendliness as the reason behind the show's success. In an interview with Parade.com, he said, "You have a show where everyone on the show relies on their talent. It’s not reality nonsense and there’s no villain and the whole family can watch it." With reality shows taking over, bringing back a world famous comedy series to television has certainly been refreshing. Brady told The Hollywood Reporter, "It's talent over bullshit."
Besides the comedy sitcom, Brady also made a name for himself as a prominent TV host when he began his variety show The Wayne Brady Show. His award-winning show collected four Emmys, two of which were given to Brady for Outstanding Talk Show Host.
Besides his two super successful TV stints, he appeared in numerous other TV sitcoms, which included How I Met Your Mother (2006-2014). His game shows Don’t Forget the Lyrics! (2007-2009), Let’s Make a Deal (2009-present) and Fast and Loose (2011) have also made him popular. His popularity grew further when he was invited to host the May 3rd, 2010 episode of Monday Night Raw (WWE).